[Bifunctional chelates of Rh-105, Au-199, and other metallic radionuclides as potential radiotherapeutic agents]

Technical Report · Tue Dec 31 00:00:00 EST 1991

DOI:https://doi.org/10.2172/10187279· OSTI ID:10187279

Progress during this period is reported under the following headings: Diethylenetriamine based and related bifunctional chelating agents and their complexation with Rh-105, Au-198, Pd-109, cu-67, In-111, and Co-57; studies of Pd-109, Rh-105 and Tc-99m with bifunctional chelates based on phenylenediamine; establishment of an appropriate protein assay method for conjugated proteins; studies of new bifunctional Bi, Tri and tetradentate amine oxime ligands with Rh-105; IgG and antibody B72.3 conjugation studies by HPLC Techniques with bifunctional metal chelates; and progress on ligand systems for Au(III).

• Research Organization: Missouri Univ., Columbia, MO (United States). Dept. of Chemistry
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-86ER60400
• OSTI ID: 10187279
• Report Number(s): DOE/ER/60400-6; ON: DE93003146
• Resource Relation: Other Information: PBD: [1991]
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
RUTHENIUM 105
CHELATING AGENTS
GOLD 199
STRUCTURE-ACTIVITY RELATIONSHIPS
AMINES
RADIOPHARMACEUTICALS
PHENOLS
PALLADIUM 109
COPPER 67
INDIUM 111
LIGANDS
PORPHYRINS
LABELLING
550604
400202
UNSEALED RADIONUCLIDES IN THERAPY
ISOTOPE EFFECTS, ISOTOPE EXCHANGE, AND ISOTOPE SEPARATION