Improved radioimmunotherapy of hematologic malignancies. Progress report, 1988--1991

Technical Report · Tue Dec 31 04:00:00 EST 1991

DOI:https://doi.org/10.2172/10112383· OSTI ID:10112383

Press, O W; Barofsky, D F

This progress report describes accomplishments under four headings, namely: The study of the relative rates of metabolic degradation of radiolabeled monoclonal antibodies (MAb) targeting tumor associated antigens; Effects of lysosomotropic amines, carboxylic ionophores, and thioamides on the retention of radiolabeled MAbs by tumor cells; Subcellular site of radioimmunoconjugate degradation and the sizes of fragments generated by intracellular metabolism of radiolabeled antibodies; and Patterns of metabolic degradation of radioimmunoconjugates made with different techniques and with different radionuclides.

• Research Organization: Oregon State Univ., Corvallis, OR (United States). Dept. of Agricultural Chemistry
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG06-88ER60696
• OSTI ID: 10112383
• Report Number(s): DOE/ER/60696--3; ON: DE94004848; BR: HA0204030/KP0102000
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703
550501
550601
550604
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
BIOLOGICAL HALF-LIFE
CATABOLISM
IODINE 125
LYSOSOMES
MONOCLONAL ANTIBODIES
PROGRESS REPORT
RADIOIMMUNOSCINTIGRAPHY
RADIOIMMUNOTHERAPY
RADIOISOTOPE PRODUCTION
RADIOPHARMACEUTICALS
TRACER TECHNIQUES
TUMOR CELLS
UNSEALED RADIONUCLIDES IN DIAGNOSTICS
UNSEALED RADIONUCLIDES IN THERAPY
UPTAKE