Improved radioimmunotherapy of hematologic malignancies. Progress report, 1988--1991

Technical Report · Tue Dec 31 00:00:00 EST 1991

DOI:https://doi.org/10.2172/10112383· OSTI ID:10112383

Press, O W; Barofsky, D F

This progress report describes accomplishments under four headings, namely: The study of the relative rates of metabolic degradation of radiolabeled monoclonal antibodies (MAb) targeting tumor associated antigens; Effects of lysosomotropic amines, carboxylic ionophores, and thioamides on the retention of radiolabeled MAbs by tumor cells; Subcellular site of radioimmunoconjugate degradation and the sizes of fragments generated by intracellular metabolism of radiolabeled antibodies; and Patterns of metabolic degradation of radioimmunoconjugates made with different techniques and with different radionuclides.

• Research Organization: Oregon State Univ., Corvallis, OR (United States). Dept. of Agricultural Chemistry
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG06-88ER60696
• OSTI ID: 10112383
• Report Number(s): DOE/ER/60696-3; ON: DE94004848; BR: HA0204030/KP0102000
• Resource Relation: Other Information: PBD: [1991]
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
MONOCLONAL ANTIBODIES
CATABOLISM
UPTAKE
BIOLOGICAL HALF-LIFE
PROGRESS REPORT
RADIOIMMUNOTHERAPY
IODINE 125
AMINES
TUMOR CELLS
RADIOIMMUNOSCINTIGRAPHY
LYSOSOMES
RADIOPHARMACEUTICALS
550604
550601
400703
550501
UNSEALED RADIONUCLIDES IN THERAPY
UNSEALED RADIONUCLIDES IN DIAGNOSTICS
RADIOISOTOPE PRODUCTION
TRACER TECHNIQUES