Improved radioimmunotherapy of hematologic malignancies

Technical Report · Fri May 12 04:00:00 EDT 1989

OSTI ID:5514112

Press, O W

In the seven months which have elapsed since initial funding of this project, considerable progress has been made towards achieving the objectives of this research. These objectives include: to study the relative rates of metabolic degradation of radiolabeled monoclonal antibodies (mAbs) targeting tumor associated antigens; to examine the effects of lysomotropic amines (ammonium chloride, chloroquine, amantadine), carboxylic ionophores (monensin), and thionamides (propylthiouracil), on the retention of radiolabeled mAbs by tumor cells; to identify the subcellular site of radioimmunoconjugate degradation, and to quantify the sizes of the fragments generated by intracellular metabolism of radiolabeled mAbs; to examine the effects of lysomotropic agents on the quality of external gamma camera imaging and radiation dosimetry generated in tumor-bearing mice injected with radiolabeled mAbs; to examine the effects of lysomotropic agents on the radiotherapeutic efficacy of radiolabeled mAbs in murine tumors and human tumors xenografted to nude mice; and to compare the effects of lysomotropic agents on the degradation of radioimmunoconjugates made with different radionuclides and different conjugation methods.

• Research Organization: Washington Univ., Seattle, WA (USA). Medical Oncology Lab.
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG06-88ER60719
• OSTI ID: 5514112
• Report Number(s): DOE/ER/60719-1; ON: DE89017444
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
DOCUMENT TYPES
DOSIMETRY
IMMUNOLOGY
IMMUNOTHERAPY
LABELLING
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MEDICINE
MICE
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEAR MEDICINE
PROGRESS REPORT
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOLOGY
RADIOTHERAPY
RODENTS
SOMATIC CELLS
THERAPY
VERTEBRATES