Improved radioimmunotherapy of hematologic malignancies. [Final report]

Technical Report · Tue Mar 24 04:00:00 EST 1992

DOI:https://doi.org/10.2172/10141667· OSTI ID:10141667

Press, O W

This research project proposes to develop novel new approaches of improving the radioimmunodetection and radioimmunotherapy of malignancies by augmenting retention of radioimmunoconjugates by tumor cells. The approaches shown to be effective in these laboratory experiments will subsequently be incorporated into out ongoing clinical trials in patients. Specific project objectives include: to study the rates of endocytosis, intracellular routing, and metabolic degradation of radiolabeled monoclonal antibodies targeting tumor-associated antigens on human leukemia and lymphoma cells; To examine the effects of lysosomotropic amines (e.g. chloroquine, amantadine), carboxylic ionophores (monensin, nigericin), and thioamides (propylthiouracil), on the retention of radiolabeled MoAbs by tumor cells; to examine the impact of newer radioiodination techniques (tyramine cellobiose, paraiodobenzoyl) on the metabolic degradation of radioiodinated antibodies; to compare the endocytosis, intracellular routing, and degradation of radioimmunoconjugates prepared with different radionuclides ({sup 131}Iodine, {sup 111}Indium, {sup 90}Yttrium, {sup 99m}Technetium, {sup 186}Rhenium); and to examine the utility of radioimmunoconjugates targeting oncogene products for the radioimmunotherapy and radioimmunoscintigraphy of cancer.

• Research Organization: Washington Univ., Seattle, WA (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG06-88ER60719
• OSTI ID: 10141667
• Report Number(s): DOE/ER/60719--T1; ON: DE92012504
• Country of Publication: United States
• Language: English

Related Subjects

550604
62 RADIOLOGY AND NUCLEAR MEDICINE
DECOMPOSITION
INDIUM 111
IODINATION
IODINE 131
LABELLED COMPOUNDS
LEUKEMIA
MONOCLONAL ANTIBODIES
NEOPLASMS
ONCOGENES
PROGRESS REPORT
RADIOIMMUNOTHERAPY
RETENTION
RHENIUM 186
TECHNETIUM 99
UNSEALED RADIONUCLIDES IN THERAPY
YTTRIUM 90