Mass spectrometric immunoassay

Nelson, Randall W.; Williams, Peter; Krone, Jennifer Reeve

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Title: Mass spectrometric immunoassay

Abstract

Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.

Inventors:: Nelson, Randall W.; Williams, Peter; Krone, Jennifer Reeve

Issue Date:: Tue Dec 13 00:00:00 EST 2005

Research Org.:: Intrinsic Bioprobes, Inc., Tempe, AZ (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1175578

Patent Number(s):: 6974704

Application Number:: 09/808,275

Assignee:: Intrinsic Bioprobes, Inc. (Tempe, AZ)

Patent Classifications (CPCs):: C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/6816 - characterised by the detection means
C12Q1/6872 - involving mass spectrometry

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N24/00 - Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
G01N33/5302 - {Apparatus specially adapted for immunological test procedures}
G01N33/54373 - {involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings}
G01N33/6851 - {Methods of protein analysis involving laser desorption ionisation mass spectrometry}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/24 - Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

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DOE Contract Number:: FG02-91ER61127

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

Citation Formats


                    Nelson, Randall W., Williams, Peter, and Krone, Jennifer Reeve. Mass spectrometric immunoassay.  United States: N. p., 2005. 
        Web.

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                    Nelson, Randall W., Williams, Peter, & Krone, Jennifer Reeve. Mass spectrometric immunoassay.  United States.

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                    Nelson, Randall W., Williams, Peter, and Krone, Jennifer Reeve. Tue .  
        "Mass spectrometric immunoassay".  United States.  https://www.osti.gov/servlets/purl/1175578.

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@article{osti_1175578,

  title        = {Mass spectrometric immunoassay},

  author       = {Nelson, Randall W. and Williams, Peter and Krone, Jennifer Reeve},

  abstractNote = {Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Dec 13 00:00:00 EST 2005},

  month        = {Tue Dec 13 00:00:00 EST 2005}

}

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Works referenced in this record:

Direct Analysis of Affinity-Bound Analytes by MALDI/TOF MS
journal, September 1994

Papac, Damon I.; Hoyes, John.; Tomer, Kenneth B.
Analytical Chemistry, Vol. 66, Issue 17
https://doi.org/10.1021/ac00089a004

Quantitative profiling of 6-ketoprostaglandin F1α, 2,3-dinor-6-ketoprostaglandin F1α, thromboxane B2 and 2,3-dinor-thromboxane B2 in human and rat urine by immunoaffinity extraction with gas chromatography—mass spectrometry
journal, January 1989

Chiabrando, Chiara; Pinciroli, Vittorio; Campoleoni, Andrea
Journal of Chromatography B: Biomedical Sciences and Applications, Vol. 495
https://doi.org/10.1016/S0378-4347(00)82604-3

Immunoaffinity Extraction of 4-Hydroxy-2-(4-methylphenyl)benzothiazole and Its Metabolites for Determination by Gas Chromatography-Mass Spectrometry.
journal, January 1994

Awata, Norio; Toba, Fumio; Ando, Masayuki
Biological & Pharmaceutical Bulletin, Vol. 17, Issue 6
https://doi.org/10.1248/bpb.17.843

Simultaneous determination of the primary prostanoids prostaglandin E2, prostaglandin F2α and 6-oxoprostaglandin F1α by immunoaffinity chromatography in combination with negative ion chemical ionization gas chromatography—tandem mass spectrometry
journal, January 1989

Mackert, Gerhard; Reinke, Margot; Schweer, Horst
Journal of Chromatography B: Biomedical Sciences and Applications, Vol. 494
https://doi.org/10.1016/S0378-4347(00)82652-3