Mass spectrometric immunoassay

Nelson, Randall W; Williams, Peter; Krone, Jennifer Reeve

Title: Mass spectrometric immunoassay

Patent · Tue Dec 04 00:00:00 EST 2007

OSTI ID:920671

Nelson, Randall W ^[1]; Williams, Peter ^[1]; Krone, Jennifer Reeve ^[2]

Phoenix, AZ
Granbury, TX

Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.

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Research Organization:: Arizona State Univ., Tempe, AZ (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-91ER61127

Assignee:: Intrinsic Bioprobes, Inc. (Tempe, AZ)

Patent Number(s):: 7,303,888

Application Number:: 11/459,471

OSTI ID:: 920671

Country of Publication:: United States

Language:: English

References (7)

Quantitative analysis of low molecular weight compounds of biological interest by matrix-assisted laser desorption ionization Duncan, Mark W.; Matanovic, Gabrijela; Cerpa-Poljak, Anne Rapid Communications in Mass Spectrometry, Vol. 7, Issue 12 https://doi.org/10.1002/rcm.1290071207	journal	December 1993
Direct Analysis of Affinity-Bound Analytes by MALDI/TOF MS Papac, Damon I.; Hoyes, John.; Tomer, Kenneth B. Analytical Chemistry, Vol. 66, Issue 17 https://doi.org/10.1021/ac00089a004	journal	September 1994
Quantitative profiling of 6-ketoprostaglandin F1α, 2,3-dinor-6-ketoprostaglandin F1α, thromboxane B2 and 2,3-dinor-thromboxane B2 in human and rat urine by immunoaffinity extraction with gas chromatography—mass spectrometry Chiabrando, Chiara; Pinciroli, Vittorio; Campoleoni, Andrea Journal of Chromatography B: Biomedical Sciences and Applications, Vol. 495 https://doi.org/10.1016/S0378-4347(00)82604-3	journal	January 1989
Immunoadsorption to improve gas chromatography/high-resolution mass spectrometry of estradiol-17 beta in plasma. Gaskell, S. J.; Brownsey, B. G. Clinical Chemistry, Vol. 29, Issue 4 https://doi.org/10.1093/clinchem/29.4.677	journal	April 1983
Quantification of steroid conjugates using fast atom bombardment mass spectrometry Gaskell, Simon J. Steroids, Vol. 55, Issue 10 https://doi.org/10.1016/0039-128X(90)90014-3	journal	October 1990
Mass Spectrometric Immunoassay Nelson, Randall W.; Krone, Jennifer R.; Bieber, Allan L. Analytical Chemistry, Vol. 67, Issue 7 https://doi.org/10.1021/ac00103a003	journal	April 1995
Epitope mapping of the gastrin-releasing peptide/anti-bombesin monoclonal antibody complex by proteolysis followed by matrix-assisted laser desorption ionization mass spectrometry Papac, Damon I.; Hoyes, John; Tomer, Kenneth B. Protein Science, Vol. 3, Issue 9 https://doi.org/10.1002/pro.5560030914	journal	September 1994

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