Focused analyte spray emission apparatus and process for mass spectrometric analysis
Abstract
An apparatus and process are disclosed that deliver an analyte deposited on a substrate to a mass spectrometer that provides for trace analysis of complex organic analytes. Analytes are probed using a small droplet of solvent that is formed at the junction between two capillaries. A supply capillary maintains the droplet of solvent on the substrate; a collection capillary collects analyte desorbed from the surface and emits analyte ions as a focused spray to the inlet of a mass spectrometer for analysis. The invention enables efficient separation of desorption and ionization events, providing enhanced control over transport and ionization of the analyte.
- Inventors:
-
- Kennewick, WA
- Richland, WA
- Issue Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1034908
- Patent Number(s):
- 8097845
- Application Number:
- 12/722,257
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Classifications (CPCs):
-
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- DOE Contract Number:
- AC05-76RL01830
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Roach, Patrick J, Laskin, Julia, and Laskin, Alexander. Focused analyte spray emission apparatus and process for mass spectrometric analysis. United States: N. p., 2012.
Web.
Roach, Patrick J, Laskin, Julia, & Laskin, Alexander. Focused analyte spray emission apparatus and process for mass spectrometric analysis. United States.
Roach, Patrick J, Laskin, Julia, and Laskin, Alexander. Tue .
"Focused analyte spray emission apparatus and process for mass spectrometric analysis". United States. https://www.osti.gov/servlets/purl/1034908.
@article{osti_1034908,
title = {Focused analyte spray emission apparatus and process for mass spectrometric analysis},
author = {Roach, Patrick J and Laskin, Julia and Laskin, Alexander},
abstractNote = {An apparatus and process are disclosed that deliver an analyte deposited on a substrate to a mass spectrometer that provides for trace analysis of complex organic analytes. Analytes are probed using a small droplet of solvent that is formed at the junction between two capillaries. A supply capillary maintains the droplet of solvent on the substrate; a collection capillary collects analyte desorbed from the surface and emits analyte ions as a focused spray to the inlet of a mass spectrometer for analysis. The invention enables efficient separation of desorption and ionization events, providing enhanced control over transport and ionization of the analyte.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 17 00:00:00 EST 2012},
month = {Tue Jan 17 00:00:00 EST 2012}
}
Works referenced in this record:
Molecular Characterization of Organic Aerosols Using Nanospray-Desorption/Electrospray Ionization-Mass Spectrometry †
journal, October 2010
- Roach, Patrick J.; Laskin, Julia; Laskin, Alexander
- Analytical Chemistry, Vol. 82, Issue 19