Site specific incorporation of keto amino acids into proteins

Patent · Tue Apr 28 00:00:00 EDT 2009

OSTI ID:986550

Schultz, Peter G ^[1]; Wang, Lei ^[2]

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1. La Jolla, CA
2. San Diego, CA

Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs.

• Research Organization: The Scripps Research Inst., La Jolla, CA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: FG03-00ER45812
• Assignee: The Scripps Research Institute (La Jolla, CA)
• Patent Number(s): 7,524,647
• Application Number: 11/978,160; TRN: US201017%%402
• OSTI ID: 986550
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
LIGASES
MACHINERY
PROTEINS