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Title: Site specific incorporation of keto amino acids into proteins

Abstract

Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs.

Inventors:
 [1];  [2]
  1. La Jolla, CA
  2. San Diego, CA
Publication Date:
Research Org.:
The Scripps Research Institute (La Jolla, CA); University of California
Sponsoring Org.:
USDOE
OSTI Identifier:
985410
Patent Number(s):
7,432,092
Application Number:
10/530,421
Assignee:
The Scripps Research Institute (La Jolla, CA) OAK
DOE Contract Number:  
FG03-00ER45812; AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Schultz, Peter G, and Wang, Lei. Site specific incorporation of keto amino acids into proteins. United States: N. p., 2008. Web.
Schultz, Peter G, & Wang, Lei. Site specific incorporation of keto amino acids into proteins. United States.
Schultz, Peter G, and Wang, Lei. Tue . "Site specific incorporation of keto amino acids into proteins". United States. https://www.osti.gov/servlets/purl/985410.
@article{osti_985410,
title = {Site specific incorporation of keto amino acids into proteins},
author = {Schultz, Peter G and Wang, Lei},
abstractNote = {Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 07 00:00:00 EDT 2008},
month = {Tue Oct 07 00:00:00 EDT 2008}
}

Patent:

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