Sleeve reaction chamber system

Patent · Tue Aug 25 00:00:00 EDT 2009

OSTI ID:968326

Northrup, M Allen ^[1]; Beeman, Barton V ^[2]; Benett, William J ^[3]; Hadley, Dean R ^[4]; Landre, Phoebe ^[3]; Lehew, Stacy L ^[3]; Krulevitch, Peter A ^[5]

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1. Berkeley, CA
2. San Mateo, CA
3. Livermore, CA
4. Manteca, CA
5. Pleasanton, CA

A chemical reaction chamber system that combines devices such as doped polysilicon for heating, bulk silicon for convective cooling, and thermoelectric (TE) coolers to augment the heating and cooling rates of the reaction chamber or chambers. In addition the system includes non-silicon-based reaction chambers such as any high thermal conductivity material used in combination with a thermoelectric cooling mechanism (i.e., Peltier device). The heat contained in the thermally conductive part of the system can be used/reused to heat the device, thereby conserving energy and expediting the heating/cooling rates. The system combines a micromachined silicon reaction chamber, for example, with an additional module/device for augmented heating/cooling using the Peltier effect. This additional module is particularly useful in extreme environments (very hot or extremely cold) where augmented heating/cooling would be useful to speed up the thermal cycling rates. The chemical reaction chamber system has various applications for synthesis or processing of organic, inorganic, or biochemical reactions, including the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: W-7405-ENG-48
• Assignee: OAK
• Patent Number(s): 7,578,976
• Application Number: 09/568,618
• OSTI ID: 968326
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY