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Title: Microfabricated sleeve devices for chemical reactions

Abstract

A silicon-based sleeve type chemical reaction chamber that combines heaters, such as doped polysilicon for heating, and bulk silicon for convection cooling. The reaction chamber combines a critical ratio of silicon and non-silicon based materials to provide the thermal properties desired. For example, the chamber may combine a critical ratio of silicon and silicon nitride to the volume of material to be heated (e.g., a liquid) in order to provide uniform heating, yet low power requirements. The reaction chamber will also allow the introduction of a secondary tube (e.g., plastic) into the reaction sleeve that contains the reaction mixture thereby alleviating any potential materials incompatibility issues. The reaction chamber may be utilized in any chemical reaction system for synthesis or processing of organic, inorganic, or biochemical reactions, such as the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction, which are examples of a synthetic, thermal-cycling-based reaction. The reaction chamber may also be used in synthesis instruments, particularly those for DNA amplification and synthesis.

Inventors:
 [1]
  1. (Berkeley, CA)
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
875073
Patent Number(s):
US 6524532
Assignee:
The Regents of the University of California (Oakland, CA) LLNL
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
microfabricated; sleeve; devices; chemical; reactions; silicon-based; type; reaction; chamber; combines; heaters; doped; polysilicon; heating; bulk; silicon; convection; cooling; critical; ratio; non-silicon; based; materials; provide; thermal; properties; example; combine; nitride; volume; material; heated; liquid; uniform; power; requirements; allow; introduction; secondary; tube; plastic; contains; mixture; alleviating; potential; incompatibility; issues; utilized; synthesis; processing; organic; inorganic; biochemical; polymerase; chain; pcr; andor; dna; ligase; examples; synthetic; thermal-cycling-based; instruments; amplification; silicon nitride; reaction chamber; reaction mixture; chemical reaction; bulk silicon; /422/435/

Citation Formats

Northrup, M. Allen. Microfabricated sleeve devices for chemical reactions. United States: N. p., 2003. Web.
Northrup, M. Allen. Microfabricated sleeve devices for chemical reactions. United States.
Northrup, M. Allen. Wed . "Microfabricated sleeve devices for chemical reactions". United States. https://www.osti.gov/servlets/purl/875073.
@article{osti_875073,
title = {Microfabricated sleeve devices for chemical reactions},
author = {Northrup, M. Allen},
abstractNote = {A silicon-based sleeve type chemical reaction chamber that combines heaters, such as doped polysilicon for heating, and bulk silicon for convection cooling. The reaction chamber combines a critical ratio of silicon and non-silicon based materials to provide the thermal properties desired. For example, the chamber may combine a critical ratio of silicon and silicon nitride to the volume of material to be heated (e.g., a liquid) in order to provide uniform heating, yet low power requirements. The reaction chamber will also allow the introduction of a secondary tube (e.g., plastic) into the reaction sleeve that contains the reaction mixture thereby alleviating any potential materials incompatibility issues. The reaction chamber may be utilized in any chemical reaction system for synthesis or processing of organic, inorganic, or biochemical reactions, such as the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction, which are examples of a synthetic, thermal-cycling-based reaction. The reaction chamber may also be used in synthesis instruments, particularly those for DNA amplification and synthesis.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {1}
}

Patent:

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