Microfabricated sleeve devices for chemical reactions
- Berkeley, CA
A silicon-based sleeve type chemical reaction chamber that combines heaters, such as doped polysilicon for heating, and bulk silicon for convection cooling. The reaction chamber combines a critical ratio of silicon and non-silicon based materials to provide the thermal properties desired. For example, the chamber may combine a critical ratio of silicon and silicon nitride to the volume of material to be heated (e.g., a liquid) in order to provide uniform heating, yet low power requirements. The reaction chamber will also allow the introduction of a secondary tube (e.g., plastic) into the reaction sleeve that contains the reaction mixture thereby alleviating any potential materials incompatibility issues. The reaction chamber may be utilized in any chemical reaction system for synthesis or processing of organic, inorganic, or biochemical reactions, such as the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction, which are examples of a synthetic, thermal-cycling-based reaction. The reaction chamber may also be used in synthesis instruments, particularly those for DNA amplification and synthesis.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- DOE Contract Number:
- W-7405-ENG-48
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Number(s):
- US 6524532
- OSTI ID:
- 875073
- Country of Publication:
- United States
- Language:
- English
A Mems-based Miniature DNA Analysis System
|
conference | January 1995 |
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Related Subjects
sleeve
devices
chemical
reactions
silicon-based
type
reaction
chamber
combines
heaters
doped
polysilicon
heating
bulk
silicon
convection
cooling
critical
ratio
non-silicon
based
materials
provide
thermal
properties
example
combine
nitride
volume
material
heated
liquid
uniform
power
requirements
allow
introduction
secondary
tube
plastic
contains
mixture
alleviating
potential
incompatibility
issues
utilized
synthesis
processing
organic
inorganic
biochemical
polymerase
chain
pcr
andor
dna
ligase
examples
synthetic
thermal-cycling-based
instruments
amplification
silicon nitride
reaction chamber
reaction mixture
chemical reaction
bulk silicon
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