Preparation of pHEMA-CP composites with high interfacial adhesionvia template-driven mineralization
We report a template-driven nucleation and mineral growth process for the high-affinity integration of calcium phosphate (CP) with a poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel scaffold. A mineralization technique was developed that exposes carboxylate groups on the surface of crosslinked pHEMA, promoting high-affinity nucleation and growth of calcium phosphate on the surface along with extensive calcification of the hydrogel interior. External factors such as the heating rate, the agitation of the mineral stock solution and the duration of the process that affect the outcome of the mineralization were investigated. This template-driven mineralization technique provides an efficient approach toward bonelike composites with high mineral-hydrogel interfacial adhesion strength.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- Office of Science. Basic Energy Sciences
- DOE Contract Number:
- DE-AC02-05CH11231
- OSTI ID:
- 918104
- Report Number(s):
- LBNL-52645; JECSER; R&D Project: 519055; BnR: KC0304000; TRN: US200817%%1121
- Journal Information:
- Journal of the European Ceramic Society, Vol. 23, Issue 15; Related Information: Journal Publication Date: 2003; ISSN 0955-2219
- Country of Publication:
- United States
- Language:
- English
Similar Records
A new approach to mineralization of biocompatible hydrogel scaffolds: An efficient process towards 3-dimensional bonelike composites
Mineralization of Synthetic Polymer Scaffolds: A Bottom-upApproach for the Development of Artificial Bone