Mineralization of Synthetic Polymer Scaffolds: A Bottom-upApproach for the Development of Artificial Bone
The controlled integration of organic and inorganic components confers natural bone with superior mechanical properties. Bone biogenesis is thought to occur by templated mineralization of hard apatite crystals by an elastic protein scaffold, a process we sought to emulate with synthetic biomimetic hydrogel polymers. Crosslinked polymethacrylamide and polymethacrylate hydrogels were functionalized with mineral-binding ligands and used to template the formation of hydroxyapatite. Strong adhesion between the organic and inorganic materials was achieved for hydrogels functionalized with either carboxylate or hydroxy ligands. The mineral-nucleating potential of hydroxyl groups identified here broadens the design parameters for synthetic bone-like composites and suggests a potential role for hydroxylated collagen proteins in bone mineralization.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE. Office of Management Budget and Evaluation,Laboratory Directed Research and Development Program; National Institutesof Health Grant R01 DE015633-01
- DOE Contract Number:
- DE-AC02-05CH11231; NIH:DE-AC03-76SF00098; NIHR01DE015633-01
- OSTI ID:
- 861167
- Report Number(s):
- LBNL-56375; R&D Project: M3CB03; BnR: 400412000; TRN: US200601%%686
- Journal Information:
- Journal of American Chemical Society, Vol. 127, Issue 10; Related Information: Journal Publication Date: 03/16/2005
- Country of Publication:
- United States
- Language:
- English
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