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Title: Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides

Patent ·
OSTI ID:880175
 [1];  [1];  [2];  [1]
  1. Germantown, MD
  2. Montgomery Village, MD
+ Show Author Affiliations

A method of inhibiting at least one molecular process in a sample, comprising administering to the sample an oligonucleotide or polynucleotide containing at least one monomeric unit having formula (I): wherein A is an organic moiety, n is at least 1, and each X is independently selected from the group consisting of --NRCOCONu, --NHCOCR.sub.2 CR.sub.2 CONu, --NHCOCR.dbd.CRCONu, and --NHCOSSCONu, wherein each R independently represents H or a substituted or unsubstituted alkyl group, and Nu represents a nucleophile, or a salt of the compound.

Research Organization:
Fidelity Systems, Inc. (Gaithersburg, MD)
DOE Contract Number:
FG02-98ER82577
Assignee:
Fidelity Systems, Inc. (Gaithersburg, MD)
Patent Number(s):
US 6548251
Application Number:
10/655804
OSTI ID:
880175
Country of Publication:
United States
Language:
English

References (11)

Drug Leads from Combinatorial Phosphodiester Libraries journal October 1995
Synthesis of functionally modified oligonucleotides from methoxyoxalamido precursors journal May 1996
Synthesis of functionally tethered oligodeoxynucleotides by the convertible nucleoside approach journal November 1990
Synthesis of N-substituted hydroxyprolinol phosphoramidites for the preparation of combinatorial libraries journal December 1994
Oxalyl-CPG: a labile support for synthesis of sensitive oligonucleotide derivatives journal January 1991
Synthesis of Suitably-Protected Phosphoramidites of 2′-Fluoro-2′-Deoxyguanosine and 2′-Amino-2′-Deoxyguanosine for Incorporation Into Oligoribonucleotides journal August 1992
Synthesis and characterization of imidazoyl-linked synthons and 3'-conjugated thymidine derivatives journal August 1993
Aminolysis of 2′-Deoxyinosine Aryl Ethers: Nucleoside Model Studies for the Synthesis of Functionally Tethered Oligonucleotides journal December 1992
Synthesis of oligonucleotides containing 2′-azido- and 2′-amino-2′-deoxyuridine using phosphotriester chemistry journal May 1996
Sequencing Oligonucleotides by Exonuclease Digestion and Delayed Extraction Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry journal June 1996
Synthesis of 2′–modified nucleotides and their incorporation into hammerhead ribozymes journal January 1995

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