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Title: Oncoprotein protein kinase

Patent ·
OSTI ID:875023
 [1];  [1];  [2];  [3];  [4]
  1. San Diego, CA
  2. La Jolla, CA
  3. Princeton, MA
  4. Shrewsbury, MA
+ Show Author Affiliations

An isolated polypeptide (JNK) characterized by having a molecular weight of 46kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.

Research Organization:
Univ. of California (United States)
DOE Contract Number:
FG03-86ER60429
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
US 6514745
Application Number:
08/220,602
OSTI ID:
875023
Country of Publication:
United States
Language:
English

References (4)

An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control journal July 1990
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. journal November 1993
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF journal May 1991
Phosphorylation of c-jun mediated by MAP kinases journal October 1991

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Related Subjects

oncoprotein
protein
kinase
isolated
polypeptide
jnk
characterized
molecular
weight
46kd
determined
reducing
sds-page
serine
threonine
activity
phosphorylating
c-jun
n-terminal
activation
domain
polynucleotide
sequences
method
detection
provided
phosphorylates
affects
expression
ap-1
sites
molecular weight
polynucleotide sequences
isolated polypeptide
protein kinase
reducing sds-page
kinase activity
oncoprotein protein
threonine kinase
/435/999/