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Oncoprotein protein kinase antibody kit

Patent ·
OSTI ID:985696
 [1];  [1];  [2]
  1. San Diego, CA
  2. La Jolla, CA
+ Show Author Affiliations

An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.

Research Organization:
University of California
Sponsoring Organization:
USDOE
DOE Contract Number:
FG03-86ER60429
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
7,468,426
Application Number:
11/521,839
OSTI ID:
985696
Country of Publication:
United States
Language:
English

References (18)

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase journal February 1990
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain journal March 1994
Parallel signal processing among mammalian MAPKs journal March 1995
Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain. journal June 1992
Induction of proto-oncogene JUN/AP-1 by serum and TPA journal August 1988
Induction of protooncogene c-jun by serum growth factors. journal November 1988
Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin. journal November 1981
Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1 journal December 1987
Phosphorylation of c-jun mediated by MAP kinases journal October 1991
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. journal November 1993
Analysis of artificial proteins by matrix-assisted laser desorption mass spectrometry journal September 1992
c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. journal October 1994
DNA-binding activity of jun is increased through its interaction with Fos journal April 1990
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control journal July 1990
Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts journal August 1988
Structure and chromosomal localization of the functional intronless human JUN protooncogene. journal December 1988
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF journal May 1991
Generation of cDNA probes directed by amino acid sequence: cloning of urate oxidase journal March 1988

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59 BASIC BIOLOGICAL SCIENCES