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Title: Oncoprotein protein kinase

Abstract

An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.

Inventors:
 [1];  [1];  [2]
  1. San Diego, CA
  2. La Jolla, CA
Publication Date:
Research Org.:
Univ. of California (United States)
OSTI Identifier:
870843
Patent Number(s):
US 5605808
Assignee:
Regents of University of California (Oakland, CA)
DOE Contract Number:  
FG03-86ER60429
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
oncoprotein; protein; kinase; isolated; polypeptide; jnk; characterized; molecular; weight; 46; kd; determined; reducing; sds-page; serine; threonine; activity; phosphorylating; c-jun; n-terminal; activation; domain; polynucleotide; sequences; method; detection; provided; phosphorylates; affects; expression; ap-1; sites; phosphorylates c-jun; oncoprotein protein; ap-1 sites; protein kinase; reducing sds-page; kinase activity; jnk phosphorylates; activation domain; nucleotide sequences; nucleotide sequence; n-terminal activation; c-jun n-terminal; molecular weight; isolated polypeptide; polynucleotide sequences; threonine kinase; protein protein; /435/

Citation Formats

Karin, Michael, Hibi, Masahiko, and Lin, Anning. Oncoprotein protein kinase. United States: N. p., 1997. Web.
Karin, Michael, Hibi, Masahiko, & Lin, Anning. Oncoprotein protein kinase. United States.
Karin, Michael, Hibi, Masahiko, and Lin, Anning. 1997. "Oncoprotein protein kinase". United States. https://www.osti.gov/servlets/purl/870843.
@article{osti_870843,
title = {Oncoprotein protein kinase},
author = {Karin, Michael and Hibi, Masahiko and Lin, Anning},
abstractNote = {An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.},
doi = {},
url = {https://www.osti.gov/biblio/870843}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {1}
}

Works referenced in this record:

An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control
journal, July 1990


Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
journal, February 1990


Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain.
journal, June 1992


Parallel signal processing among mammalian MAPKs
journal, March 1995


Phosphorylation of c-jun mediated by MAP kinases
journal, October 1991