Hybridization and sequencing of nucleic acids using base pair mismatches

Fodor, Stephen P. A.; Lipshutz, Robert J; Huang, Xiaohua

Title: Hybridization and sequencing of nucleic acids using base pair mismatches

Patent · Mon Jan 01 00:00:00 EST 2001

OSTI ID:873966

Fodor, Stephen P. A. ^[1]; Lipshutz, Robert J ^[1]; Huang, Xiaohua ^[2]

Palo Alto, CA
Mt. View, CA

Devices and techniques for hybridization of nucleic acids and for determining the sequence of nucleic acids. Arrays of nucleic acids are formed by techniques, preferably high resolution, light-directed techniques. Positions of hybridization of a target nucleic acid are determined by, e.g., epifluorescence microscopy. Devices and techniques are proposed to determine the sequence of a target nucleic acid more efficiently and more quickly through such synthesis and detection techniques.

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Research Organization:: Affymax Research Institute

DOE Contract Number:: FG03-92ER81275

Assignee:: Affymetrix Inc. (Santa Clara, CA)

Patent Number(s):: US 6284460

OSTI ID:: 873966

Country of Publication:: United States

Language:: English

References (8)

Sequencing of megabase plus DNA by hybridization: Theory of the method Dramanac, Radoje; Labat, Ivan; Brukner, Ivan Genomics, Vol. 4, Issue 2, p. 114-128 https://doi.org/10.1016/0888-7543(89)90290-5	journal	February 1989
Sequencing of pools of nucleic acids on oligonucleotide arrays Chetverin, Alexander B.; Kramer, Fred Russell Biosystems, Vol. 30, Issue 1-3 https://doi.org/10.1016/0303-2647(93)90072-K	journal	January 1993
Likelihood DNA Sequencing By Hybridization Lipshutz, Robert J. Journal of Biomolecular Structure and Dynamics, Vol. 11, Issue 3 https://doi.org/10.1080/07391102.1993.10508020	journal	December 1993
An oligonucleotide hybridization approach to DNA sequencing Khrapko, K. R.; P. Lysov, Yu; Khorlyn, A. A. FEBS Letters, Vol. 256, Issue 1-2, p. 118-122 https://doi.org/10.1016/0014-5793(89)81730-2	journal	October 1989
Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: Evaluation using experimental models Southern, E. M.; Maskos, U.; Elder, J. K. Genomics, Vol. 13, Issue 4, p. 1008-1017 https://doi.org/10.1016/0888-7543(92)90014-J	journal	August 1992
DNA sequencing with chain-terminating inhibitors Sanger, F.; Nicklen, S.; Coulson, A. R. Proceedings of the National Academy of Sciences, Vol. 74, Issue 12 https://doi.org/10.1073/pnas.74.12.5463	journal	December 1977
Analysis of DNA Oligonucleotide Hybridization Data by Maximum Entropy Elder, J. K. Maximum Entropy and Bayesian Methods https://doi.org/10.1007/978-94-017-2217-9_44	book	January 1993
A new method for sequencing DNA. Maxam, A. M.; Gilbert, W. Proceedings of the National Academy of Sciences, Vol. 74, Issue 2 https://doi.org/10.1073/pnas.74.2.560	journal	February 1977

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Related Subjects

hybridization
sequencing
nucleic
acids
base
pair
mismatches
devices
techniques
determining
sequence
arrays
formed
preferably
resolution
light-directed
positions
target
acid
determined
epifluorescence
microscopy
proposed
determine
efficiently
quickly
synthesis
detection
detection techniques
nucleic acid
nucleic acids
target nucleic
base pair
epifluorescence microscopy
light-directed techniques
target nuclei
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Title: Hybridization and sequencing of nucleic acids using base pair mismatches

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References (8)

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