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Title: Co-factor activated recombinant adenovirus proteinases

Patent ·
OSTI ID:870544
 [1];  [2]
  1. Stony Brook, NY
  2. Shoreham, NY
+ Show Author Affiliations

This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying said peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described.

Research Organization:
Associated Universities, Inc., Upton, NY (United States)
DOE Contract Number:
AC02-76CH00016
Assignee:
Associated Universities, Inc. (Washington, DC)
Patent Number(s):
US 5543264
Application Number:
US patent applicaiton 08/155,171
OSTI ID:
870544
Country of Publication:
United States
Language:
English

References (13)

Viral DNA and a viral peptide can act as cofactors of adenovirus virion proteinase activity journal January 1993
Expression and Purification of the Adenovirus Proteinase Polypeptide and of a Synthetic Proteinase Substrate journal February 1993
Characterization of the adenovirus 2 virion protein, Mu journal October 1989
Human Adenovirus Serotype 12 Virion Precursors pMu and pVI Are Cleaved at Amino-Terminal and Carboxy-Terminal Sites That Conform to the Adenovirus 2 Endoproteinase Cleavage Consensus Sequence journal March 1993
Adenovirus proteinases: comparison of amino acid sequences and expression of the cloned cDNA in Escherichia coli journal April 1990
Adenovirus type 2 endopeptidase: an unusual phosphoprotein enzyme matured by autocatalysis. journal February 1987
Gly-Gly-X, a Novel Consensus Sequence for the Proteolytic Processing of Viral and Cellular Proteins journal June 1989
In vitro cleavage specificity of the adenovirus type 2 proteinase journal March 1983
The adenovirus protease is activated by a virus-coded disulphide-linked peptide journal January 1993
Adenovirus type 2 precursor proteins are cleaved by proteinases of other adenoviruses journal November 1990
The active adenovirus protease is the intact L3 23K protein journal July 1993
Characterization of the Adenovirus Proteinase: Substrate Specificity journal December 1989
Genetic identification of a endoproteinase endoded by the adenovirus genome journal June 1983

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Related Subjects

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/435/999/