Activated recombinant adenovirus proteinases

Anderson, Carl W; Mangel, Walter F

Activated recombinant adenovirus proteinases

Patent · Thu Dec 31 23:00:00 EST 1998

OSTI ID:872441

Anderson, Carl W ^[1]; Mangel, Walter F ^[2]

Stony Brook, NY
Shoreham, NY

This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying said peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY

Assignee:: Associated Universities, Inc. (Washington, DC)

Patent Number(s):: US 5935840

Application Number:: 08/435,998

OSTI ID:: 872441

Country of Publication:: United States

Language:: English

References (19)

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The active adenovirus protease is the intact L3 23K protein Webster, A.; Kemp, G. Journal of General Virology, Vol. 74, Issue 7 https://doi.org/10.1099/0022-1317-74-7-1415	journal	July 1993
Nucleotide and deduced amino acid sequence of the bovine adenovirus type 3 proteinase Cai, Faxing; Bourbonnière, Martin; Tang, Denis Nucleic Acids Research, Vol. 18, Issue 18 https://doi.org/10.1093/nar/18.18.5568	journal	January 1990
Human Adenovirus Serotype 12 Virion Precursors pMu and pVI Are Cleaved at Amino-Terminal and Carboxy-Terminal Sites That Conform to the Adenovirus 2 Endoproteinase Cleavage Consensus Sequence Freimuth, Paul; Anderson, Carl W. Virology, Vol. 193, Issue 1 https://doi.org/10.1006/viro.1993.1131	journal	March 1993
Characterization of the Adenovirus Proteinase: Substrate Specificity Webster, A.; Russell, S.; Talbot, P. Journal of General Virology, Vol. 70, Issue 12 https://doi.org/10.1099/0022-1317-70-12-3225	journal	December 1989
Sequence of the protease of human subgroup E adenovirus type 4 Houde, A.; Weber, J. M. Gene, Vol. 54, Issue 1 https://doi.org/10.1016/0378-1119(87)90346-5	journal	January 1987
Isolation and properties of adenovirus type 2 proteinase. Tihanyi, K.; Bourbonnière, M.; Houde, A. Journal of Biological Chemistry, Vol. 268, Issue 3 https://doi.org/10.1016/S0021-9258(18)53921-1	journal	January 1993
The adenovirus protease is activated by a virus-coded disulphide-linked peptide Webster, Ailsa; Hay, Ronald T.; Kemp, Graham Cell, Vol. 72, Issue 1 https://doi.org/10.1016/0092-8674(93)90053-S	journal	January 1993
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Gly-Gly-X, a Novel Consensus Sequence for the Proteolytic Processing of Viral and Cellular Proteins López-Otín, C.; Simón-Mateo, C.; Martínez, L. Journal of Biological Chemistry, Vol. 264, Issue 16 https://doi.org/10.1016/S0021-9258(18)60496-X	journal	June 1989
Adenovirus type 2 precursor proteins are cleaved by proteinases of other adenoviruses Houde, Alain; Weber, Joseph M. Virology, Vol. 179, Issue 1 https://doi.org/10.1016/0042-6822(90)90321-H	journal	November 1990
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References (19)

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