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Title: Triamine chelants, their derivatives, complexes and conjugates

Patent ·
OSTI ID:869774
 [1];  [2];  [3]
  1. Phoenixville, PA
  2. Gaithersburg, MD
  3. Vashi, IN
+ Show Author Affiliations

A group of functionalized triamine chelants and their derivatives that form complexes with radioactive metal ions are disclosed. The complexes can be covalently attached to a protein or an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. The chelants are of the formula: ##STR1## wherein n, m, R, R.sup.1, R.sup.2 and L are defined in the specification.

Research Organization:
Univ. of Missouri, Columbia, MO (United States)
DOE Contract Number:
FG02-86ER60400
Assignee:
Curators of University of Missouri (Columbia, MO)
Patent Number(s):
US 5395608
OSTI ID:
869774
Country of Publication:
United States
Language:
English

References (8)

Cobalt(III) Complexes with 4-Methyldiethylene-triamine[2,2'-Methyliminodi(ethylamine)]: Their Separation, Characterization and Reactions journal January 1979
Formation and stabilities of cobalt(II) chelates of N-benzyl triamine Schiff bases and their dioxygen complexes journal February 1984
Synthesis of 1-(p-isothiocyanatobenzyl) derivatives of DTPA and EDTA. Antibody labeling and tumor-imaging studies journal July 1986
Some iron(III) complexes with polydentate Schiff base ligands journal July 1988
Labeling of human IgG with rhodium-105 using a new pentadentate bifunctional ligand journal May 1990
Technetium( V ) and rhenium( V ) complexes with Schiff-base ligands containing the ONNNO donor atom set. Crystal structure of [N,N′-3-azapentane-1,5-diylbis(salicylideneiminato)(3–)-O,O′,N,N′,N″]-oxotechnetium( V ) journal January 1988
Synthesis, plasma clearance, and in vitro stability of protein containing a conjugated indium-111 chelate journal September 1980
Comparative evaluation of 99mTc-labeled aminothiols as possible brain perfusion imaging agents journal January 1988

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triamine
chelants
derivatives
complexes
conjugates
functionalized
form
radioactive
metal
disclosed
covalently
attached
protein
antibody
fragment
therapeutic
diagnostic
purposes
formula
str1
defined
specification
radioactive metal
active metal
triamine chelants
antibody fragment
diagnostic purposes
covalently attached
functionalized triamine
form complexes
/424/530/999/