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Triamines and their derivatives as bifunctional chelating agents

Patent ·
OSTI ID:868223
 [1];  [2];  [1]
  1. Columbia, MO
  2. Hovertown, PA
+ Show Author Affiliations

A group of functionalized triamine chelants and their derivatives that form complexes with radioactive metal ions are disclosed. The complexes can be covalently attached to a protein or an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes.

Research Organization:
University of Missouri
DOE Contract Number:
FG02-86ER60400
Assignee:
Curators of University of Missouri (Columbia, MO)
Patent Number(s):
US 5101041
Application Number:
07/343,472
OSTI ID:
868223
Country of Publication:
United States
Language:
English

References (7)

Formation and stabilities of cobalt(II) chelates of N-benzyl triamine Schiff bases and their dioxygen complexes journal February 1984
Technetium( V ) and rhenium( V ) complexes with Schiff-base ligands containing the ONNNO donor atom set. Crystal structure of [N,N′-3-azapentane-1,5-diylbis(salicylideneiminato)(3–)-O,O′,N,N′,N″]-oxotechnetium( V ) journal January 1988
Synthesis of 1-(p-isothiocyanatobenzyl) derivatives of DTPA and EDTA. Antibody labeling and tumor-imaging studies journal July 1986
Some iron(III) complexes with polydentate Schiff base ligands journal July 1988
Comparative evaluation of 99mTc-labeled aminothiols as possible brain perfusion imaging agents journal January 1988
Synthesis, plasma clearance, and in vitro stability of protein containing a conjugated indium-111 chelate journal September 1980
Cobalt(III) Complexes with 4-Methyldiethylene-triamine[2,2'-Methyliminodi(ethylamine)]: Their Separation, Characterization and Reactions journal January 1979

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Related Subjects

/999/424/530/
active metal
agents
antibody
antibody fragment
attached
bifunctional
bifunctional chelating
chelants
chelating
chelating agent
chelating agents
complexes
covalently
covalently attached
derivatives
diagnostic
diagnostic purposes
disclosed
form
form complexes
fragment
functionalized
functionalized triamine
metal
protein
purposes
radioactive
radioactive metal
therapeutic
triamine
triamine chelants
triamines