Human Genetic Marker for Resistance to Radiation and Chemicals

Technical Report · Fri May 11 00:00:00 EDT 2001

DOI:https://doi.org/10.2172/789807· OSTI ID:789807

Lieberman, Howard B

TO characterize the human HRDAD9 gene and evaluate its potential as a biomarker to predict susceptibility to the deleterious health effects potentially caused by exposure to radiations or chemicals present at DOE hazardous waste cleanup sites. HRAD9 is a human gene that is highly conserved throughout evolution. Related genes have been isolated from yeasts and mice, underscoring its biological significance. Most of our previous work involved characterization of the yeast gene cognate, wherein it was determined that the corresponding protein plays a significant role in promoting resistance of cells to radiations and chemicals, and in particular, controlling cell growth in response to DNA damage.

• Research Organization: The Trustees of Columbia University in The City of New York (US)
• Sponsoring Organization: (US)
• DOE Contract Number: FG07-96ER62309
• OSTI ID: 789807
• Report Number(s): DOE/ER/62309; 55100; TRN: US0200645
• Resource Relation: Other Information: PBD: 11 May 2001
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS
DNA DAMAGES
GENES
GENETICS
MICE
PROTEINS
IONIZING RADIATIONS
YEASTS
BIOLOGICAL INDICATORS
CHEMICAL WASTES
RADIATIONS
CHEMICALS
HUMAN GENETIC
HAZARDOUS WASTE