Human Genetic Marker for Resistance to Radiations and Chemicals
The major objective of this project is to understand the genetic basis for resistance of humans to radiations and chemicals. In the fission yeast S. pombe, a gene called rad9 plays a key role in promoting resistance to DNA damaging agents and controlling cell cycle progression after radiation or chemical exposure. This investigation focuses on the characterization of a human homologue of this yeast gene, called HRAD9, with the longterm goal of developing the gene as a genetic marker to predict inherent susceptibility to the deleterious health effects caused by DNA damage. The aims concern a molecular characterization of HRAD9 and determination of its role in mediating the cellular response to radiations and chemicals, as well as its potential role in carcinogenesis.
- Research Organization:
- Columbia University, New York, NY (US)
- Sponsoring Organization:
- USDOE Office of Environmental Management (EM) (US)
- DOE Contract Number:
- FG07-96ER62309
- OSTI ID:
- 827399
- Report Number(s):
- EMSP-55100-2000; R&D Project: EMSP 55100; TRN: US200425%%640
- Resource Relation:
- Other Information: PBD: 1 Jun 2000
- Country of Publication:
- United States
- Language:
- English
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Human Genetic Marker for Resistance to Radiations and Chemicals
Human genetic marker for resistance to radiations and chemicals. 1998 annual progress report