New prodrugs based on phospholipid-nucleoside conjugates

Patent · Wed Feb 03 00:00:00 EST 1982

OSTI ID:6710935

MacCoss, M.

A method is described for the preparation of defined, isomerically pure phospholipid-nucleoside conjugates as a prodrug in which the drug (araC) is attached to the phospholipid by a monophosphate linkage. Key intermediates in the process involve selective blocking and deblocking of the nucleoside derivative. These particular monophosphate-linked derivatives represent a new class of prodrug, which are useful by themselves or in combination with diphosphate linked derivatives. Several new compositions involving diphosphate linked derivatives are described in which the products are isomerically pure and having defined fatty acid chain lengths.

• DOE Contract Number: W-31-109-ENG-38
• Assignee: Dept. of Energy
• Patent Number(s): PATENTS-US-A345442
• Application Number: ON: DE83002391
• OSTI ID: 6710935
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTINEOPLASTIC DRUGS
CHEMICAL PREPARATION
CHEMICAL BONDS
NUCLEOSIDES
PHOSPHATES
PHOSPHOLIPIDS
DRUGS
ESTERS
LIPIDS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
RIBOSIDES
SYNTHESIS
550200* - Biochemistry
550600 - Medicine