Phospholipid-nucleoside conjugates. 5. The interaction of selected 1-. beta. -D-arabinofuranosylcytosine-5'-diphosphate-L-1,2-diacylglycerols with serum lipoproteins

Journal Article · Mon Oct 31 04:00:00 EST 1983 · Biochem. Biophys. Res. Commun.; (United States)

DOI:https://doi.org/10.1016/0006-291X(83)90531-4· OSTI ID:5229489

MacCoss, M; Edwards, J J; Lagocki, P; Rahman, Y E

The phospholipid-nucleoside conjugates 1-..beta..-d-arabinofuranosylcytosine-5'-diphosphate-L-1,2-dipalmitin, -distearin, and -diolein have been shown to interact rapidly with canine high density lipoprotein and with both high density and low density lipoproteins isolated from human serum. The extent of interaction with the high density lipoproteins appears to be dependent upon the characteristic gel-liquid crystalline phase transition of the conjugate's phospholipid. Since the phospholipid-nucleoside conjugates under study represent sustained release forms of the antileukemic agent 1-..beta..-D-arabinofuranosylcytosine, the therapeutic efficacy of these conjugates should now be considered in light of these interactions.

• Research Organization: Argonne National Lab., IL
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 5229489
• Journal Information: Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 116:2; ISSN BBRCA
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
ANTINEOPLASTIC DRUGS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BLOOD SERUM
DRUGS
ESTERS
HYDROXY COMPOUNDS
KINETICS
LIPIDS
LIPOPROTEINS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHOLIPIDS
PROTEINS
REACTION KINETICS
RIBOSIDES