Phospholipid derivatives of nucleoside analogs as prodrugs with enhanced catabolic stability
Journal Article
·
· Cancer Res.; (United States)
OSTI ID:6721132
- Argonne National Lab., IL
The nucleoside 5'-diphosphate-L-1,2-dipalmitin derivatives of 1-..beta..-D-arabinofuranosylcytosine (ara-D), 9-..beta..-D-arabinofuranosyladenine (ara-A), and tubercidin have been synthesized, and their cytotoxicity has been evaluated against a mouse myeloma cell line (MPC-11) in vitro and against L1210 lymphoid leukemia both in vitro and in vivo. Sonication methods were utilized to solubilize these lipophilic derivatives in aqueous solution in order to facilitate such biological evaluation; the ara-A derivative resisted solubilization by several techniques. (JMT)
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 6721132
- Journal Information:
- Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 41; ISSN CNREA
- Country of Publication:
- United States
- Language:
- English
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Journal Article
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Sun Oct 30 23:00:00 EST 1983
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OSTI ID:5229489
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·
Fri May 01 00:00:00 EDT 1987
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
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OSTI ID:6076595
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Patent
·
Tue Feb 02 23:00:00 EST 1982
·
OSTI ID:6710935
Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTINEOPLASTIC DRUGS
CATABOLISM
CELL KILLING
DISEASES
DRUGS
ESTERS
EVALUATION
HEMIC DISEASES
IN VITRO
IN VIVO
INHIBITION
LEUKEMIA
LIPIDS
MAMMALS
METABOLISM
MICE
NEOPLASMS
NUCLEOSIDES
NUCLEOTIDES
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHOLIPIDS
RIBOSIDES
RODENTS
SOLUBILITY
SYNTHESIS
TUMOR CELLS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTINEOPLASTIC DRUGS
CATABOLISM
CELL KILLING
DISEASES
DRUGS
ESTERS
EVALUATION
HEMIC DISEASES
IN VITRO
IN VIVO
INHIBITION
LEUKEMIA
LIPIDS
MAMMALS
METABOLISM
MICE
NEOPLASMS
NUCLEOSIDES
NUCLEOTIDES
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHOLIPIDS
RIBOSIDES
RODENTS
SOLUBILITY
SYNTHESIS
TUMOR CELLS
VERTEBRATES