Prospects for cellular mutational assays in human populations

Conference · Fri Jun 29 00:00:00 EDT 1984

OSTI ID:6656999

Mendelsohn, M L

Practical, sensitive, and effective human cellular assays for detecting somatic and germinal mutations would have great value in environmental mutagenesis and carcinogenesis studies. Such assays would fill the void between human mutagenicity and the data that exist from short-term tests and from mutagenicity in other species. This paper discusses the following possible human cellular assays: (1) HPRT (hypoxanthine phosphoribosyltransferase) somatic cell mutation based on 6-thioguanine resistance; (2) hemoglobin somatic cell mutation assay; (3) glycophorin somatic cell mutation assay; and (4) LDH-X sperm cell mutation assay. 18 references.

• Research Organization: Lawrence Livermore National Lab., CA (USA)
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 6656999
• Report Number(s): UCRL-90841; CONF-8405207-1; ON: DE84014706
• Resource Relation: Conference: Symposium on assessment of risk from low level exposure to radiation and chemicals, Upton, NY, USA, 20 May 1984
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MUTAGEN SCREENING
FEASIBILITY STUDIES
BIOASSAY
ERYTHROCYTES
LYMPHOCYTES
MAN
SOMATIC CELLS
SPERMATOZOA
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
GAMETES
GERM CELLS
LEUKOCYTES
MAMMALS
MATERIALS
PRIMATES
SCREENING
VERTEBRATES
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)