Human somatic mutation assays as biomarkers of carcinogenesis

Journal Article · Thu Aug 01 00:00:00 EDT 1991 · Environmental Health Perspectives; (United States)

DOI:https://doi.org/10.2307/3431307· OSTI ID:6093984

Compton, P J.E.; Smith, M T ^[1]; Hooper, K ^[2]

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1. Univ. of California, Berkeley (United States)
2. California Dept. of Health Services, Berkeley (United States)

This paper describes four assays that detect somatic gene mutations in humans: the hypoxanthine-guanine phosphoribosyl transferase assay, the glycophorin A assay, the HLA-A assay, and the sickle cell hemoglobin assay. Somatic gene mutations can be considered a biomarker of carcinogenesis, and assays for somatic mutation may assist epidemiologists in studies that attempt to identify factors associated with increased risks of cancer. Practical aspects of the use of these assays are discussed.

• OSTI ID: 6093984
• Journal Information: Environmental Health Perspectives; (United States), Journal Name: Environmental Health Perspectives; (United States) Vol. 94; ISSN 0091-6765; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
BIOASSAY
BIOLOGICAL MARKERS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
CARCINOGENESIS
DISEASES
ENZYMES
EPIDEMIOLOGY
ERYTHROCYTES
GLOBINS
GLYCOSYL TRANSFERASES
HEMIC DISEASES
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE
MATERIALS
MEMBRANE PROTEINS
MUTATIONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
PENTOSYL TRANSFERASES
PIGMENTS
PORPHYRINS
PROTEINS
RISK ASSESSMENT
SICKLE CELL ANEMIA
SOMATIC MUTATIONS
SYMPTOMS
TRANSFERASES