Bovine lymphocytic leukemia: studies of etiology, pathogenesis and mode of transmission. Progress report No. 18, June 1975--June 1978

Technical Report · Sat Jul 01 00:00:00 EDT 1978

DOI:https://doi.org/10.2172/6371351· OSTI ID:6371351

Sorensen, D. K.

The primary objective of this research is to elucidate the cause(s) and early pathogenesis of the adult form of lymphosarcoma in cattle. Consequently, a major portion of our research is centered around experimental transmission of this disease. Bovine leukemia is believed to be caused by an oncogenic RNA virus designated bovine leukemia virus (BLV). We have consistently demonstrated the presence of BLV particles in leukemic cattle and cattle with a persistent lymphocytosis, but never in normal cattle. These BLV particles have been partially purified and highly concentrated to provide a potent inoculum used to inoculate 12 late stage bovine fetuses (in utero) and two newborn calves. Our current study involves extensive monitoring of these inoculated animals to detect early precancerous changes and obtain a detailed description of the events occurring early in the pathogenesis of bovine lymphosarcoma. From our ongoing monitoring study we will be able to detail when, in what sequence, and to what extent each parameter changes in the course of lymphosarcoma development. In addition to our transmission and monitoring studies we are examining various lymphocyte subpopulations in an attempt to determine which cell type is responsible for BLV production and to determine if this same cell type carries the nuclear pocket abnormality associated with the adult form of bovine lymphosarcoma. (ERB)

• Research Organization: Minnesota Univ., St. Paul (USA). Coll. of Veterinary Medicine
• DOE Contract Number: EY-76-S-02-0910
• OSTI ID: 6371351
• Report Number(s): COO-0910-47
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CATTLE
LEUKEMIA
LYMPHOSARCOMAS
ETIOLOGY
LEUKEMIA VIRUS
LEUKEMOGENESIS
AGE DEPENDENCE
LYMPHOCYTES
PATHOLOGICAL CHANGES
PATHOGENESIS
EXPERIMENTAL DATA
INFECTIVITY
ISOLATED VALUES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARCINOGENESIS
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DISEASES
DOMESTIC ANIMALS
HEMIC DISEASES
INFORMATION
LEUKOCYTES
LYMPHOMAS
MAMMALS
MICROORGANISMS
NEOPLASMS
NUMERICAL DATA
ONCOGENIC VIRUSES
PARASITES
RUMINANTS
SARCOMAS
SOMATIC CELLS
VERTEBRATES
VIRUSES
550900* - Pathology
550700 - Microbiology
550300 - Cytology