Phenomenological models
The biological effects of ionizing radiation exposure are the result of a complex sequence of physical, chemical, biochemical, and physiological interactions. One way to begin a search for an understanding of health effects of radiation is through the development of phenomenological models of the response. Many models have been presented and tested in the slowly evolving process of characterizing cellular response. A range of models covering different endpoints and phenomena has developed in parallel. Many of these models employ similar assumptions about some underlying processes while differing about the nature of others. An attempt is made to organize many of the models into groups with similar features and to compare the consequences of those features with the actual experimental observations. It is assumed that by showing that some assumptions are inconsistent with experimental observations, the job of devising and testing mechanistic models can be simplified. 43 refs., 13 figs.
- Research Organization:
- Pacific Northwest Lab., Richland, WA (USA)
- Sponsoring Organization:
- DOE/ER
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 6365078
- Report Number(s):
- PNL-SA-18754; CONF-9009267-3; ON: DE91004737
- Resource Relation:
- Conference: Physical and chemical mechanisms in molecular radiation biology conference, Woods Hole, MA (USA), 3-7 Sep 1990
- Country of Publication:
- United States
- Language:
- English
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ACUTE IRRADIATION
RADIATION HAZARDS
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
MATHEMATICAL MODELS
CELL CYCLE
CHROMOSOMAL ABERRATIONS
DNA
DNA REPAIR
DOSE RATES
LET
RADIATION QUALITY
ACUTE EXPOSURE
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
ENERGY TRANSFER
HAZARDS
HEALTH HAZARDS
IRRADIATION
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RECOVERY
REPAIR
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture