Mammary tumors and serum hormones in the bitch treated with medroxyprogesterone acetate or progesterone for four years

Technical Report · Sun Jan 01 00:00:00 EST 1978

DOI:https://doi.org/10.2172/6162791· OSTI ID:6162791

Frank, D. W.; Kirton, K. T.; Murchison, T. E.; Quinlan, W. J.; Coleman, M. E.; Gilbertson, T. J.; Feenstra, E. S.; Kimball, F. A.

After four years of a long term contraceptive steroid safety study, the incidence and the histologic type of mammary dysplasia produced is similar in beagles treated with medroxyprogesterone acetate (medroxyprogesterone) or progesterone. Serum insulin, thyroid stimulating hormone (TSH), triiodothyronine, growth hormone, prolactin, 17..beta..-estradiol, progesterone, and cortisol were determined by radioimmunoassay on samples collected after 45 months of treatment. Serum growth hormone and insulin concentrations were elevated in a dose related manner in both treatment groups. Triiodothyronine, cortisol, and estradiol-17..beta.. (medroxyprogesterone only) were lowered. TSH and prolactin concentrations were not changed. Pituitary--gonadal hormone interaction in the pathogenesis of mammary neoplasia of the dog is discussed. Prolonged treatment of the beagle with massive doses of progesterone or medroxyprogesterone results in a dose related incidence of mammary modules.

• Research Organization: Upjohn Co., Kalamazoo, MI (USA); Dawson Research Corp., Orlando, FL (USA); Rochester Univ., NY (USA). Dept. of Radiation Biology and Biophysics
• DOE Contract Number: EY-76-C-02-3490
• OSTI ID: 6162791
• Report Number(s): UR-3490-1550
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOGENESIS
DOSE-RESPONSE RELATIONSHIPS
ESTRADIOL
RADIOIMMUNOASSAY
HYDROCORTISONE
HYDROXYPREGNENONE
INSULIN
LTH
NEOPLASMS
ETIOLOGY
PROGESTERONE
STH
TRIIODOTHYRONINE
TSH
BEAGLES
BLOOD SERUM
CHRONIC EXPOSURE
EXPERIMENTAL DATA
FEMALES
INTRAMUSCULAR INJECTION
ISOLATED VALUES
MAMMARY GLANDS
ADRENAL HORMONES
ANIMALS
BODY
CORTICOSTEROIDS
DATA
DATA FORMS
DISEASES
DOGS
ESTRANES
ESTROGENS
GLANDS
GLUCOCORTICOIDS
GONADOTROPINS
HORMONES
HYDROXY COMPOUNDS
INFORMATION
INJECTION
INTAKE
ISOTOPE APPLICATIONS
KETONES
MAMMALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PEPTIDE HORMONES
PITUITARY HORMONES
PREGNANES
RADIOASSAY
STEROID HORMONES
STEROIDS
THYROID HORMONES
TRACER TECHNIQUES
VERTEBRATES
550901* - Pathology- Tracer Techniques
550601 - Medicine- Unsealed Radionuclides in Diagnostics