CO-induction of rat intestinal cancers with 7,12-dimethylbenz(a)anthracene and medroxyprogesterone acetate

Conference · Sat Mar 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5414772

Hass, G; Galt, R; Coogan, P; Friese, J

Medroxy progesterone acetate (P) is a progestin used for treatment of sex hormone-dependent human cancers. In a study of its action, 7,12-dimethyl-benz(a)anthracene (DMBA) was given, i.g., to 50-52 day old intact or gonadectomized Sprague-Dawley rats of both sexes. Groups were given 0, 5, 25 or 100 mg of P +/- 2, .5, .1, .01 or .001 mg of 17 beta estradiol (E2), s.c., each week for 12-36 weeks. Those given P often developed, independent of sex or gonadectomy, multiple intestinal adenomas and carcinomas, especially in the jejunum. At doses of P tumor incidence was as follows: 0 mg, 2/63; 5 mg, 18/96; 25 mg, 35/57; 100 mg, 72/155. Combinations of P with doses of E2 at 2, .5 or .1 mg reduced tumor incidence 65%. At 25 or 100 mg doses of P, DMBA induction of mammary tumors was inhibited, while atrophy of ovaries and adrenal cortex was impressive. Hence, this is the only progestin, which favors DMBA induction of tumors of the rat intestine, while extinguishing mammary tumors. This matter may bear on presence of hormone receptors in human colo-rectal cancers.

• Research Organization: Augustana Hospital, Chicago, IL
• OSTI ID: 5414772
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOMAS
ADRENAL GLANDS
ANIMALS
AROMATICS
BENZANTHRACENE
BODY
CARCINOGENESIS
CARCINOMAS
CONDENSED AROMATICS
DIGESTIVE SYSTEM
DISEASE INCIDENCE
DISEASES
ENDOCRINE GLANDS
ESTRADIOL
ESTRANES
ESTROGENS
FEMALE GENITALS
GASTROINTESTINAL TRACT
GLANDS
GONADS
HORMONES
HYDROCARBONS
HYDROXY COMPOUNDS
INTESTINES
KETONES
MAMMALS
MAMMARY GLANDS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
OVARIES
PATHOGENESIS
PREGNANES
PROGESTERONE
RATS
RODENTS
SMALL INTESTINE
STEROID HORMONES
STEROIDS
VERTEBRATES