Study of the combined effects of smoking and inhalation of uranium ore dust, radon daughters and diesel oil exhaust fumes in hamsters and dogs. Final report
Exposure to particulates from uranium ore dust and diesel exhaust soot provoked inflammatory and proliferative responses in lungs. Also exposure to radon and radon daughters yielded increased occurrences of bronchiolar epithelial hyperplasia and metaplastic changes of alveolar epithelium. The data suggest that this cellular change is also a precursor of premalignant change in hamsters. The authors suggest an animal model other than the hamster based on two observations: (1) the Syrian golden hamster has been shown to be highly refractory to carcinoma induction; and (2) that when exposed to realistic levels of agents in life-span exposure regimens, the hamster does not develop lesions. Dog studies with cigarette smoke exposure showed mitigating effects on radon daughter induced respiratory tract cancer. Two reasons are suggested although no empirical evidence was gathered. A strict comparison of human and animal exposures and interpolative models are not possible at this time. (PCS)
- Research Organization:
- Battelle Pacific Northwest Labs., Richland, WA (United States)
- DOE Contract Number:
- EY-76-C-06-1830
- OSTI ID:
- 5818313
- Report Number(s):
- PNL-2744
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARCINOGENESIS
BIOLOGICAL MODELS
DIESEL FUELS
HEALTH HAZARDS
TOBACCO SMOKES
AEROSOLS
DAUGHTER PRODUCTS
DIESEL ENGINES
DOGS
DUSTS
EXHAUST GASES
HAMSTERS
INHALATION
LUNGS
MAN
NEOPLASMS
PARTICLES
PATHOLOGICAL CHANGES
PHYSIOLOGY
RADON
RESPIRATORY SYSTEM
SOOT
URANIUM ORES
ANIMALS
BODY
COLLOIDS
DISEASES
DISPERSIONS
ELEMENTS
ENGINES
FUELS
GASEOUS WASTES
HAZARDS
INTAKE
INTERNAL COMBUSTION ENGINES
ISOTOPES
MAMMALS
NONMETALS
ORES
ORGANS
PATHOGENESIS
PRIMATES
RARE GASES
RESIDUES
RODENTS
SMOKES
SOLS
VERTEBRATES
WASTES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)