Fly ash-induced changes in hamster tracheal epithelium in vivo and in vitro
- IIT Research Inst., Chicago, IL
The effects of fly ash from a coal-fired power plant on tracheal epithelium of CrRGH (SYR) Syrian golden hamsters were studied in organ cultures and after in vivo exposures. The tracheal epithelium of animals receiving 5-9 daily (5 d/wk) 3-h exposures to 2 mg fly ash per cubic meter showed large areas of basal cell hyperplasia and stratification. Surface alterations characteristic of stratified metaplasia were observed. Exposure to 1 mg/m/sup 3/ produced diffuse basal cell hyperplasia. Hamster tracheal ring cultures exposed in vitro to 50 ..mu..g/ml fly ash for 1 h/d or to 10 ..mu..g/ml for 3 h/d showed epithelial changes similar to those observed in vivo. Whole suckling hamster tracheas in organ culture exposed to fly ash at concentrations of 10 and 50 ..mu..g/ml for 1 or 3 h/d exhibited cornifying epidermoid metaplasia after 7 exposures. The most characteristic findings in surface cells were broad metaplastic areas with keratin formation.
- OSTI ID:
- 5868932
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 8:3; ISSN JTEHD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
010900 -- Coal
Lignite
& Peat-- Environmental Aspects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ANIMALS
ASHES
BIOLOGICAL EFFECTS
CARBONACEOUS MATERIALS
COAL
ENERGY SOURCES
FLY ASH
FOSSIL FUELS
FOSSIL-FUEL POWER PLANTS
FUELS
HAMSTERS
IN VITRO
IN VIVO
MAMMALS
MATERIALS
POWER PLANTS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
THERMAL POWER PLANTS
TRACHEA
VERTEBRATES
WASTES