Pathologic changes induced by coal-fired fly ash in hamster tracheal grafts
The toxicity of fly ash from a coal-fired power plant for respiratory tract epithelium was studied in heterotropic tracheal grafts. Hamster tracheal grafts were continuously exposed to beeswax-cholesterol pellets containing 100, 1000 and 5000 micrograms fly ash and evaluated at 1, 2, 4, and 14-15 months of exposure. Histopathologic effects and the autoradiographic pattern of (/sup 3/H)thymidine incorporation were determined. In all concentrations of fly ash, an early mild submucosal inflammatory response was seen. Morphologic response of the tracheal epithelium was characterized by hyperplasia followed by squamous metaplasia and atrophic lesions. Although a rare papillomatous structure with cellular atypia was seen in grafts receiving 1000 micrograms fly ash, no carcinomas appeared during the 15-month observation period. Varying degrees of submucosal toxicity were also observed during the time period. Autoradiographic studies showed a significant increase in (/sup 3/H)thymidine incorporation in grafts receiving fly-ash treatment.
- Research Organization:
- IIT Research Inst., Chicago, IL (USA). Life Sciences Div.
- OSTI ID:
- 6962584
- Report Number(s):
- PB-87-115648/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
010900 -- Coal
Lignite
& Peat-- Environmental Aspects
500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ANIMALS
ASHES
AUTORADIOGRAPHY
AZINES
FLY ASH
HAMSTERS
HETEROCYCLIC COMPOUNDS
LABELLED COMPOUNDS
LABORATORY ANIMALS
MAMMALS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
PATHOLOGICAL CHANGES
POWER PLANTS
PYRIMIDINES
RESIDUES
RESPIRATORY SYSTEM
RIBOSIDES
RODENTS
THYMIDINE
TRITIUM COMPOUNDS
VERTEBRATES
WASTES