Mixed ligand chelate therapy for plutonium and toxic metals from energy power production. Progress report, October 15, 1978-October 14, 1979
It is shown that a mixed ligand chelate (MLC) is superior to that of the primary chelate alone for the decorporation of monomeric plutonium. Thus, EDTA plus Tiron reduces the level of Pu in the skeleton to about 40% less than that of EDTA alone when treatment was begun two hrs post /sup 239/Pu. However, DTPA alone was still superior to EDTA/Tiron under the given experimental conditions. However, this appears to be due to the rapid metabolic destruction of secondary chelants such as Tiron and similar bi-dentate derivatives of catechol and salicylates. Investigations are under way to improve such MLC's by the use of metabolic inhibitors to increase the plasma concentrations and residence times of the secondary chelants. In addition, MLC's consisting of metabolically stable chelants are undergoing testing. Therapy of cadmium poisoned mice by single and mixed chelants is also under study. A molar ratio of EDTA to Cd of 1.6 reduces the mortality by half of female mice given 5 min (i.p.) post supralethal doses of CdCl/sub 2/, while a molar ratio of 4.7 for 2, 3-dimercaptopropanol-1-sulfonate (DMPS) is required. No protection is observed with penicillamine (PA) or salicylates (SA) alone. However, combinations of EDTA with both PA and DMPS or SA and DMPS afford protection under conditions (30 min post Cd) where the individual chelants are ineffective. Automated potentiometric titrations are utilized to detect MLC formation and to evaluate their stability. The titration data are used as a screening procedure to ascertain whether a given chelant combination is worth testing in vivo.
- Research Organization:
- Hope Coll., Holland, MI (USA). Div. of Natural Sciences
- DOE Contract Number:
- EE-77-S-02-4369
- OSTI ID:
- 5774488
- Report Number(s):
- COO-4369-2; TRN: 79-022499
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHELATING AGENTS
BIOLOGICAL EFFECTS
DTPA
EDTA
LIVER
RADIONUCLIDE KINETICS
PLUTONIUM 239
EXCRETION
TIRON
SKELETON
BAL
CADMIUM
MERCURY
PENICILLAMINE
SALICYLIC ACID
SULFONIC ACID ESTERS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALI METAL COMPOUNDS
ALPHA DECAY RADIOISOTOPES
AMINO ACIDS
ANIMALS
AROMATICS
BODY
CARBOXYLIC ACIDS
CLEARANCE
DATA
DATA FORMS
DIGESTIVE SYSTEM
DITHIOLS
DRUGS
ELEMENTS
ESTERS
EVEN-ODD NUCLEI
GLANDS
HEAVY NUCLEI
HYDROXY ACIDS
HYDROXY COMPOUNDS
INFORMATION
INJECTION
INTAKE
ISOTOPES
MAMMALS
METALS
NUCLEI
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PHENOLS
PLUTONIUM ISOTOPES
POLYPHENOLS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
REAGENTS
RESPONSE MODIFYING FACTORS
RODENTS
SODIUM COMPOUNDS
SULFONIC ACIDS
TESTING
THIOLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)