Late effects of whole brain irradiation within the therapeutic range
Whole brain exposure with supervoltage x irradiation was carried out in three sets of Macaca mulatta. Two sets of 12 monkeys each, at puberty, received single and fractionated exposures, respectively. One set of 21 monkeys in adulthood received a fractionated exposure. Exposure to 1000 rads in a single dose, at puberty, caused no late effects. Exposure to 1500 rads caused small areas of necrosis in the forebrain white matter at 26 weeks, but a much more extensive involvement at and beyond 52 weeks that included confluent areas of necrosis in gray and white matter. Brain loss resulted in ventricular dilatation. Gliomas appeared in two out of three monkeys at or beyond 52 weeks. Exposure to 2000 rads caused such a wide scatter of focal areas of necrosis, including those in the brain stem, that survival beyond 20 to 26 weeks was not possible. All showed enlarged ventricular systems. Whole brain exposure, 200 rads a day, five days a week, for a course of 4000 rads, at puberty, resulted in no delayed effects. Whole brain exposure to 6000 rads in a six weeks course, in the adult, produced less effects than the same dose at puberty. The onset of the scattered necrotic lesions was later than expected, appearing in one out of three animals at 33 weeks, two out of three animals at 52 weeks, and two out of three at 104 weeks. The lesions at 104 weeks were predominantly mineralized, but were accompanied by a greater extent of telangiectasia than seen in the pubescent monkeys.
- Research Organization:
- National Institutes of Health, Bethesda, Md. (USA); Brookhaven National Lab., Upton, N.Y. (USA)
- DOE Contract Number:
- EY-76-C-02-0016
- OSTI ID:
- 5111584
- Report Number(s):
- BNL-24069; CONF-780306-6; TRN: 78-010043
- Resource Relation:
- Conference: Symposium on late biological effects of ionizing radiation, Vienna, Austria, 13 Mar 1978; Other Information: Portions of document are illegible
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BIOLOGICAL RADIATION EFFECTS
AGE DEPENDENCE
DOSE-RESPONSE RELATIONSHIPS
BRAIN
NEOPLASMS
NECROSIS
RADIOINDUCTION
ACUTE IRRADIATION
ADOLESCENTS
ADULTS
DELAYED RADIATION EFFECTS
FRACTIONATED IRRADIATION
MONKEYS
NERVOUS SYSTEM DISEASES
PATHOLOGICAL CHANGES
TIME DEPENDENCE
X RADIATION
ACUTE EXPOSURE
ANIMALS
BIOLOGICAL EFFECTS
BODY
CENTRAL NERVOUS SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MAN
NERVOUS SYSTEM
ORGANS
PRIMATES
RADIATION EFFECTS
RADIATIONS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals