Delayed brain damage in adult monkeys from radiation in the therapeutic range

Journal Article · Wed Oct 31 23:00:00 EST 1979 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575057· OSTI ID:5685583

Wakisaka, W ^[1]; O'Neill, R R; Kemper, T L; Verrelli, D M; Caveness, W F

---

1. National Institutes of Health, Bethesda, MD

Twenty-one adult Macaca mulatta that received 6000 rad of supervoltage x irradiation in 30 fractions, alternate sides of the brain being exposed on alternate days, showed widely scattered minute necrotic lesions in the forebrain white matter in one out of three monkeys at 33 weeks, two out of three at 52 weeks, and two out of three at 104 weeks. With passage of time there was an increasing number of lesions with a trend toward mineralization except for those that extended into the cerebral cortex. Accompanying the necrotic lesions were both focal vascular endothelial hyperplasia and patches of telangiectasis.

• OSTI ID: 5685583
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 80:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
INJURIES
IRRADIATION
MAMMALS
MEDICINE
MONKEYS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
PRIMATES
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOLOGY
RADIOTHERAPY
THERAPY
VERTEBRATES