Compositions and methods for inhibiting kinase activity
Patent
·
OSTI ID:1892675
The present invention features therapeutic compositions comprising an agent that specifically binds to a PIF pocket of Aurora A kinase and an agent that specifically binds to an ATP-binding site of Aurora A kinase, and the use of the therapeutic compositions to modulate Aurora A kinase for the treatment of cancer.
- Research Organization:
- Brandeis Univ., Waltham, MA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG02-05ER15699; GM096053; GM100966-01
- Assignee:
- Brandeis University (Waltham, MA)
- Patent Number(s):
- 11,266,616
- Application Number:
- 16/075,550
- OSTI ID:
- 1892675
- Resource Relation:
- Patent File Date: 02/08/2017
- Country of Publication:
- United States
- Language:
- English
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