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Title: Compositions and methods for modulating kinase activity

Patent ·
OSTI ID:1840386
;

The present invention features an antibody mimetic, or an antigen binding fragment thereof, that specifically binds to an allosteric site of Aurora A kinase, therapeutic compositions comprising this antibody mimetic, and the use of the monobody to modulate Aurora A kinase for the treatment of cancer.

Research Organization:
Brandeis Univ., Waltham, MA (United States)
Sponsoring Organization:
USDOE; National Institutes of Health (NIH)
DOE Contract Number:
FG02-05ER15699; GM096053; GM100966-01
Assignee:
Brandeis University (Waltham, MA)
Patent Number(s):
11,104,741
Application Number:
15/774,747
OSTI ID:
1840386
Resource Relation:
Patent File Date: 01/27/2016
Country of Publication:
United States
Language:
English

References (9)

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain journal July 2016
Molecular Affinity Clamp Technology and Uses Thereof patent-application June 2011
Crystal structure of enzyme and uses thereof patent-application April 2006
A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain journal March 2010
Crystals of an Aurora-A Tpx2 Complex, Tpx2 Binding Site of Aurora-A, Aurora-A Ligands and Their Use patent-application February 2008
Allosteric Protein Kinase Modulators patent-application February 2012
Phospho-regulation of human protein kinase Aurora-A: analysis using anti-phospho-Thr288 monoclonal antibodies journal June 2006
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2 journal June 2016
High-Throughput Ligand Discovery Reveals a Sitewise Gradient of Diversity in Broadly Evolved Hydrophilic Fibronectin Domains journal September 2015

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