Cross-Kingdom Comparative Genomics of Aromatic Catabolic Pathways in Fungi and Bacteria
The overall goal of this project is to test the hypothesis that white-rot fungi can simultaneously depolymerize lignin extracellularly and catabolize depolymerization products intracellularly as carbon and energy sources. The results from this project will lead to improved understanding of lignin utilization by white-rot fungi, and enable identification of promising fungal strains for lignin catabolism and valorization. As part of this effort, we have conducted a comparative genomic study to investigate a diversity of aromatic catabolic pathways in the fungal and bacterial kingdoms. Furthermore, we have combined genomic and phylogenetic approaches to decipher the evolution of certain aromatic catabolic enzymes and discover new classes of enzymes, which represents a foundation for future biochemical and molecular genetic studies.
- Research Organization:
- National Renewable Energy Lab. (NREL), Golden, CO (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- DOE Contract Number:
- AC36-08GO28308
- OSTI ID:
- 1888025
- Report Number(s):
- NREL/PO-2800-81850; MainId:82623; UUID:025e975f-5e01-4cb2-8e1a-6d398955a13f; MainAdminID:65387
- Resource Relation:
- Conference: Presented at the Genomic Sciences Program Annual Principal Investigator Meeting, 28 February - 2 March 2022
- Country of Publication:
- United States
- Language:
- English
Similar Records
Intracellular pathways for lignin catabolism in white-rot fungi
Lignin depolymerization by fungal secretomes and a microbial sink