Antibody evolution immunogens

Patent · Tue Dec 01 00:00:00 EST 2020

OSTI ID:1771680

Haynes, Barton F.; Liao, Hua-Xin; Lynch, Rebecca M.; Zhou, Tongqing; Gao, Feng; Boyd, Scott; Shaw, George M.; Hahn, Beatrice H.; Kepler, Thomas B.; Korber, Bette T.; Kwong, Peter; Mascola, John R.

The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC52-06NA25396
• Assignee: Duke University (Durham, NC); Triad National Security, LLC (Los Alamos, NM); The Trustees of the University of Pennsylvania (Philadelphia, PA); TRUSTEES OF BOSTON UNIVERSITY (Boston, MA); The United States of America, as represented by the Secretary, Department of Health and Human Services (Rockville, MD); The Board of Trustees of the Leland Stanford Junior University (Palo Alto, CA)
• Patent Number(s): 10,849,970
• Application Number: 15/864,822
• OSTI ID: 1771680
• Resource Relation: Patent File Date: 01/08/2018
• Country of Publication: United States
• Language: English