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Title: Laser ablation spectrometry system

Patent ·
OSTI ID:1735027

This disclosure provides systems, methods, and apparatus related to laser ablation spectrometry systems. In one aspect, a system comprises a microscope, a laser, a continuous flow probe, and a gas confinement device. The laser is positioned to emit light through an objective lens of the microscope. The continuous flow probe is coupled to a spectrometer. An end of the continuous flow probe is positioned proximate a sample and between the sample and the objective lens. The gas confinement device defines a gas inlet, a chamber, a platform, a wall surrounding the platform, a plurality of vents, and a plurality of channels. Each of the plurality of vents is positioned to direct a gas substantially parallel to the platform, and each of the plurality of vents is defined in the wall. The plurality of channels is operable to provide fluid communication between the chamber and the plurality of vents.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
10,714,326
Application Number:
16/170,434
OSTI ID:
1735027
Resource Relation:
Patent File Date: 10/25/2018
Country of Publication:
United States
Language:
English

References (5)

Ambient Ionization Mass Spectrometry Imaging Platform for Direct Mapping from Bulk Tissue patent-application February 2018
Rapid and label-free procedure for microbial community screening and profiling patent March 2018
Laser ablation cell patent-application September 2014
Ambient infrared laser ablation mass spectrometry (AIRLAB-MS) with plume capture by continuous flow solvent probe patent October 2017
Ambient Infrared Laser Ablation Mass Spectrometry (AIRLAB-MS) with Plume Capture by Continuous Flow Solvent Probe patent-application January 2017