Structural and histone binding studies of the chromo barrel domain of TIP60

Zhang, Yuzhe; Lei, Ming; Yang, Xiajie; Feng, Yue; Yang, Yuan; Loppnau, Peter; Li, Yanjun; Yang, Yi; Min, Jinrong; Liu, Yanli

doi:10.1002/1873-3468.13021

Title: Structural and histone binding studies of the chromo barrel domain of TIP60

Journal Article · Sun Mar 25 00:00:00 EDT 2018 · FEBS Letters

DOI:https://doi.org/10.1002/1873-3468.13021· OSTI ID:1439636

Zhang, Yuzhe ^[1]; Lei, Ming ^[2]; Yang, Xiajie ^[1]; Feng, Yue ^[3]; Yang, Yuan ^[4]; Loppnau, Peter ^[3]; Li, Yanjun ^[3]; Yang, Yi ^[4]; Min, Jinrong ^[2]; Liu, Yanli ^[2]

Central China Normal Univ., Wuhan (China)
Central China Normal Univ., Wuhan (China); Univ. of Toronto, ON (Canada)
Univ. of Toronto, ON (Canada)
Wuhan Sports Univ. (China)

Tat-interactive protein 60 consists of an N-terminal chromo barrel domain (TIP60-CB) and a C-terminal acetyltransferase domain and acetylates histone and nonhistone proteins in diverse cellular processes. While TIP60-CB is thought to recognize histone tails, molecular details of this interaction remain unclear. In this work, we attempted a quantitative analysis of the interaction between the human TIP60-CB and histone peptides, but did not observe any detectable binding by either fluorescence polarization or isothermal titration calorimetry assays. We also determined the crystal structure of the TIP60-CB alone. Analysis of the apo-tructure reveals a putative peptide-binding site that might be occluded by the basic side chain of a residue in a unique β hairpin between the two N-terminal strands of the β barrel, leading to the inability of TIP60-CB to bind histones.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); National Natural Science Foundation of China (NSFC); Hubei Chenguang Talented Youth Development Foundation; AbbVie; Bayer Pharma AG; Boehringer Ingelheim; Canada Foundation for Innovation; Eshelman Institute for Innovation; Genome Canada; Ontario Genomics Institute; Innovative Medicines Initiative; Janssen; Merck KGaA; MSD; Novartis Pharma AG; Ontario Ministry of Research, Innovation and Science (MRIS); Pfizer; São Paulo Research Foundation (FAPESP); Takeda; Wellcome

Grant/Contract Number:: AC02-06CH11357; 31500613; 115766

OSTI ID:: 1439636

Alternate ID(s):: OSTI ID: 1464428

Journal Information:: FEBS Letters, Vol. 592, Issue 7; ISSN 0014-5793

Publisher:: Federation of European Biochemical SocietiesCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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Cited by: 6 works

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Title: Structural and histone binding studies of the chromo barrel domain of TIP60

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