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Title: Methods for increasing production of 3-methyl-2-butenol using fusion proteins

Patent ·
OSTI ID:1353075
;

The present invention relates to methods and compositions for increasing production of 3-methyl-2-butenol in a de novo synthetic pathway in a genetically modified host cell using isopentenyl disphosphate (IPP) as a substrate.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
Assignee:
The Regents of the University of California
Patent Number(s):
9,631,210
Application Number:
14/345,147
OSTI ID:
1353075
Resource Relation:
Patent File Date: 2012 Sep 13
Country of Publication:
United States
Language:
English

References (7)

Structural genomics of enzymes involved in sterol/isoprenoid biosynthesis journal November 2001
A Soluble Form of Phosphatase in Saccharomyces cerevisiae Capable of Converting Farnesyl Diphosphate Into E-E Farnesol journal January 2006
Identification of Cys139 and Glu207 As Catalytically Important Groups in the Active Site of Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase journal April 1994
Catalytic Mechanism of Escherichia coli Isopentenyl Diphosphate Isomerase Involves Cys-67, Glu-116, and Tyr-104 as Suggested by Crystal Structures of Complexes with Transition State Analogues and Irreversible Inhibitors journal January 2003
Crystal Structures of Human IPP Isomerase: New Insights into the Catalytic Mechanism journal March 2007
The Crystal Structure of Human Isopentenyl Diphosphate Isomerase at 1.7 Å Resolution Reveals its Catalytic Mechanism in Isoprenoid Biosynthesis journal March 2007
Stereochemical Studies on the Making and Unmaking of Isopentenyl Diphosphate in Different Biological Systems journal September 2004

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