Survival after total-body irradiation. 1. Effects of partial small bowel shielding
The small intestine of the rat was shielded during total-body irradiation (TBI) to evaluate the effects of radiation dose and length of intestine shielded on survival. Sprague-Dawley rats were anesthetized in groups of 10. Using aseptic surgical procedures 80, 40, 20, or 10 cm, or none of the proximal or distal small intestine were temporarily exteriorized and shielded during irradiation with photons from an 18-MeV linear accelerator. Less than 17% of the dose was delivered to the shielded intestines. In unshielded animals deaths occurred from Days 4 to 6 with 13, 15, or 17 Gy and from Days 8 to 30 with 9, 11, and 12 Gy. However, in all animals exposed to 15 Gy with all or part of the small intestine shielded, survival was increased to between 5 and 9 days. Shielding of the distal small intestine. The previously identified target of radiation damage in the small intestine is the crypt stem cell. In this study, the analysis of histological specimens of shielded and irradiated small intestine suggested that humoral factors also influence intestinal histology and survival after irradiation. These humoral factors are thought to originate from the irradiated body tissues, the shielded proximal intestine, and the shielded distal intestine. Further studies are required to identify these factors and to determine their mode of action and their therapeutic potential after radiation damage to the small intestine.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 7243303
- Report Number(s):
- AD-A-214524/1/XAB; AFRRI-SR-89-39
- Resource Relation:
- Other Information: Pub. in Radiation Research, Vol. 119, 313-324(1989)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
RATS
WHOLE-BODY IRRADIATION
SMALL INTESTINE
BIOLOGICAL SHIELDING
SURVIVAL TIME
BIOLOGICAL RADIATION EFFECTS
BODY
HISTOLOGY
LABORATORY ANIMALS
PHOTONS
RADIATION DOSES
STEM CELLS
THERAPY
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
DIGESTIVE SYSTEM
DOSES
ELEMENTARY PARTICLES
EXTERNAL IRRADIATION
GASTROINTESTINAL TRACT
INTESTINES
IRRADIATION
MAMMALS
MASSLESS PARTICLES
ORGANS
RADIATION EFFECTS
RODENTS
SHIELDING
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals