Misoprostol in the intestinal lumen protects against radiation injury of the mucosa of the small bowel
Journal Article
·
· Radiation Research; (United States)
- Univ. of Minnesota Medical School, Minneapolis, MN (United States)
Systemically administered misoprostol, a PGE analog, has been shown to be an intestinal radioprotector. The purpose of this study was to determine if administration of misoprostol into the intestinal lumen can also reduce the severity of acute radiation enteritis. The rat small bowel was operatively exteriorized and segmented by means of suture ties. The remainder of the intestine and the rat were shielded in a lead box. Misoprostol was introduced into the lumen in various doses. After 30 min exposure to misoprostol, the isolated, exteriorized, segmented bowel was subjected to 11 Gy X irradiation. Five days later the animals were sacrificed and the intestines harvested for evaluation. Surviving crypt numbers per circumference and mucosal height were the criteria used for quantification of damage. Mucosa exposed to misoprostol at the time of radiation delivery showed significantly increased crypt numbers and mucosal height compared to adjacent saline-filled intestine. 24 refs., 2 figs., 2 tabs.
- OSTI ID:
- 6551151
- Journal Information:
- Radiation Research; (United States), Journal Name: Radiation Research; (United States) Vol. 137:3; ISSN 0033-7587; ISSN RAREAE
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMALS
BIOLOGICAL PATHWAYS
BODY
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
ENTERITIS
GASTROINTESTINAL TRACT
INTESTINES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
ORGANS
RADIATION SYNDROME
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
VERTEBRATES
X RADIATION
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMALS
BIOLOGICAL PATHWAYS
BODY
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
ENTERITIS
GASTROINTESTINAL TRACT
INTESTINES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
ORGANS
RADIATION SYNDROME
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
VERTEBRATES
X RADIATION